Brief communication Open Access
Marginal vitamin C status is associated with reduced fat oxidation
during submaximal exercise in young adults
Carol S Johnston*1, Corinne Corte1 and Pamela D Swan2
Address: 1Department of Nutrition, Arizona State University, Mesa, USA and 2Department of Exercise and Wellness, Arizona State University,
Email: Carol S Johnston* – email@example.com; Corinne Corte – firstname.lastname@example.org; Pamela D Swan – email@example.com
* Corresponding author
Background: Vitamin C is a cofactor in the biosynthesis of carnitine, a molecule required for the
oxidation of fatty acids. A reduction in the ability to oxidize fat may contribute to the reported
inverse relationship between vitamin C status and adiposity. To examine this possibility, we
conducted a preliminary trial to evaluate the impact of vitamin C status on fat oxidation during
Methods: Fat energy expenditure was determined in individuals with marginal (n = 15) or
adequate (n = 7) vitamin C status during a submaximal, 60-minute treadmill test. Subsequently,
eight of the subjects with marginal vitamin C status completed an 8-week double-blind, placebocontrolled,
depletion-repletion trial with submaximal exercise testing.
Results: Individuals with marginal vitamin C status oxidized 25% less fat per kg body weight during
the treadmill test as compared to individuals with adequate vitamin C status. Fat oxidation during
exercise was inversely related to fatigue (r = -0.611, p = 0.009). Vitamin C repletion of vitamin C
depleted subjects (500 mg vitamin C/d) raised fat energy expenditure during exercise 4-fold as
compared to depleted control subjects (p = 0.011).
Conclusion: These preliminary results show that low vitamin C status is associated with red…………….